Interactions of Taking Flexeril

Medicines that interact with cyclobenzaprine may either decrease its effect, affect how long it works for, increase side effects, or have less of an effect when taken with cyclobenzaprine. An interaction between two medications does not always mean that you must stop taking one of the medications; however, sometimes it does. Speak to your doctor about how drug interactions should be managed.

Common medications that may interact with cyclobenzaprine include:

    • anti-anxiety medications
    • anticonvulsants
    • antidepressants, such as amitriptyline, imipramine, nortriptyline
    • antihistamines that cause sedation, such as diphenhydramine
    • duloxetine
    • monoamine oxidase inhibitors, such as selegiline, isocarboxazid, or phenelzine (interaction may be life-threatening)
    • opioid analgesics such as oxycodone and morphine
    • other muscle relaxants such as methocarbamol
    • sleeping pills, such as zolpidem
    • some chemotherapy treatments
    • some medications used to treat mental illness, such as clozapine and thioridazine
    • topiramate.

Alcohol may worsen the side effects of cyclobenzaprine such as drowsiness and dizziness.

Note that this list is not all-inclusive and includes only common medications that may interact with cyclobenzaprine. You should refer to the prescribing information for cyclobenzaprine for a complete list of interactions.