What is the Advantages and Disadvantages of Taking Flexeril ?

1. Advantages

  • Relieves muscle spasms associated with acute, painful, musculoskeletal conditions.
  • Improves pain, tenderness, and range of motion associated with muscle spasms and increases a person’s ability to perform their day-to-day activities.
  • Cyclobenzaprine is the most studied skeletal muscle relaxant.
  • Relieves skeletal muscle spasm without interfering with muscle function.
  • The sedative effects of cyclobenzaprine may help those experiencing insomnia as a result of muscle spasms.
  • Long-lasting effects.
  • Cyclobenzaprine has not been associated with addiction; however, abrupt discontinuation may produce symptoms such as nausea, headache, and a general feeling of discomfort. The dosage of cyclobenzaprine is best tapered off slowly on discontinuation.
  • Generic cyclobenzaprine is available.

2. Disadvantages

If you are between the ages of 18 and 60, take no other medication or have no other medical conditions, side effects you are more likely to experience include:

  • Sedation. This is a major side effect and it may impair reaction skills and affect a person’s ability to drive or operate machinery. Avoid alcohol
  • Other common side effects include dry mouth, fatigue, difficulty with urination, an increase in eye pressure, headache, dizziness, blurred vision, or nausea
  • Should only be used short-term (for periods of up to two to three weeks only)
  • Not effective for muscle spasms occurring as a result of cerebral or spinal cord disease, or in children with cerebral palsy
  • Cyclobenzaprine should never be given within 14 days of monoamine oxidase (MAO) inhibitor antidepressants, as the combination may be fatal
  • Interaction with other drugs that also increase serotonin (such as antidepressants, tramadol, St John’s Wort, bupropion) may cause serotonin syndrome. Symptoms include mental status changes (such as agitation, hallucinations, coma, delirium), fast heart rate, dizziness, flushing, muscle tremor or rigidity, and stomach symptoms (including nausea, vomiting, and diarrhea)
  • Cyclobenzaprine may enhance the effects or side effects of tricyclic antidepressants (for example, amitriptyline and imipramine), alcohol, and other CNS depressants
  • May not be suitable for people with arrhythmias, heart block or conduction disturbances, heart failure, hyperthyroidism, or immediately following a heart attack
  • The dosage of cyclobenzaprine should be reduced in people with mild liver disease. It should not be taken by people with moderate-to-severe liver disease
  • Cyclobenzaprine may not be suitable for people with glaucoma or increased intraocular pressure, a history of urinary retention, or taking other drugs that also have anticholinergic side effects (anticholinergic side effects include constipation, blurred vision, and increase in eye pressure).
  • Ineffective for muscle spasms due to brain injury or disease.
  • Elderly people may be more sensitive to the effects of cyclobenzaprine, and the dosage should be kept low if the benefits of using it in seniors outweigh the risks.

What you should know before you take Flexeril ?

What is Flexeril?

Flexeril is a muscle relaxant. It works by blocking nerve impulses (or pain sensations) that are sent to your brain.


Flexeril is used together with rest and physical therapy to treat skeletal muscle conditions such as pain, injury, or spasms.

Flexeril may also be used for purposes not listed in this medication guide.


You should not use Flexeril if you have a thyroid disorder, heart block, congestive heart failure, a heart rhythm disorder, or you have recently had a heart attack.

Do not use cyclobenzaprine if you have taken an MAO inhibitor in the past 14 days, such as isocarboxazid, linezolid, phenelzine, rasagiline, selegiline, or tranylcypromine.

Before taking this medicine

You should not use Flexeril if you are allergic to cyclobenzaprine, or if you have:

      • a thyroid disorder;
      • heart block, heart rhythm disorder, congestive heart failure;
      • or if you have recently had a heart attack.

Flexeril is not approved for use by anyone younger than 15 years old.

Do not use Flexeril if you have taken an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, phenelzine, rasagiline, selegiline, and tranylcypromine.

Some medicines can interact with cyclobenzaprine and cause a serious condition called serotonin syndrome.  Be sure your doctor knows if you also take stimulant medicine, opioid medicine, herbal products, or medicine for depression, mental illness, Parkinson’s disease, migraine headaches, serious infections, or prevention of nausea and vomiting. Ask your doctor before making any changes in how or when you take your medications.

To make sure Flexeril is safe for you, tell your doctor if you have ever had:

      • liver disease;
      • glaucoma;
      • enlarged prostate; or
      • problems with urination.

It is not known whether cyclobenzaprine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.

It may not be safe to breast-feed while using this medicine. Ask your doctor about any risk.

Older adults may be more sensitive to the effects of this medicine.

Flexeril Dosage

Generic name: cyclobenzaprine hydrochloride


Dosage form: Tablets

For most patients, the recommended dose of FLEXERIL is 5 mg three times a day. Based on individual patient response, the dose may be increased to 10 mg three times a day. Use of FLEXERIL for periods longer than two or three weeks is not recommended.

Less frequent dosing should be considered for hepatically impaired or elderly patients