What other drugs will affect Flexeril?

Using Flexeril with other drugs that make you drowsy can worsen this effect. Ask your doctor before using opioid medication, a sleeping pill, a muscle relaxer, or medicine for anxiety or seizures.

Tell your doctor about all your other medicines, especially:

      • bupropion (Zyban, for smoking cessation);
      • meperidine;
      • tramadol;
      • verapamil;
      • narcotics;
      • cold or allergy medicine that contains an antihistamine (Benadryl and others);
      • medicine to treat Parkinson’s disease;
      • medicine to treat excess stomach acid, stomach ulcer, motion sickness, or irritable bowel syndrome;
      • medicine to treat overactive bladder; or
      • bronchodilator asthma medication.

This list is not complete. Other drugs may interact with cyclobenzaprine, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.