Interactions of Taking Flexeril

Medicines that interact with cyclobenzaprine may either decrease its effect, affect how long it works for, increase side effects, or have less of an effect when taken with cyclobenzaprine. An interaction between two medications does not always mean that you must stop taking one of the medications; however, sometimes it does. Speak to your doctor about how drug interactions should be managed.

Common medications that may interact with cyclobenzaprine include:

    • anti-anxiety medications
    • anticonvulsants
    • antidepressants, such as amitriptyline, imipramine, nortriptyline
    • antihistamines that cause sedation, such as diphenhydramine
    • duloxetine
    • monoamine oxidase inhibitors, such as selegiline, isocarboxazid, or phenelzine (interaction may be life-threatening)
    • opioid analgesics such as oxycodone and morphine
    • other muscle relaxants such as methocarbamol
    • sleeping pills, such as zolpidem
    • some chemotherapy treatments
    • some medications used to treat mental illness, such as clozapine and thioridazine
    • topiramate.

Alcohol may worsen the side effects of cyclobenzaprine such as drowsiness and dizziness.

Note that this list is not all-inclusive and includes only common medications that may interact with cyclobenzaprine. You should refer to the prescribing information for cyclobenzaprine for a complete list of interactions.

What is the Tips of Taking Flexeril ?

  • Cyclobenzaprine may be taken with or without food.
  • Cyclobenzaprine should be taken in addition to rest and physical therapy.
  • The effective dosage of cyclobenzaprine varies between individuals. Take cyclobenzaprine exactly as directed by your doctor. Talk with your doctor if you experience any worrying side effects or cyclobenzaprine is not effective.
  • Cyclobenzaprine is usually only given for a maximum of two to three weeks. Your doctor may advise tapering off the dose slowly when it is time to discontinue it.
  • Cyclobenzaprine is likely to make you sleepy or impair your judgment time. Avoid operating machinery, driving, or performing tasks that require mental alertness while taking this medicine.
  • Avoid alcohol while taking this medicine. Alcohol may potentiate the side effects of cyclobenzaprine.
  • Talk to your doctor or pharmacist before taking any other medications while you are taking cyclobenzaprine. Contact your doctor urgently if you experience any mental status changes (such as agitation, hallucinations, coma, delirium), fast heart rate, dizziness, flushing, muscle tremor or rigidity, and stomach symptoms (including nausea, vomiting, and diarrhea).
  • Tell your doctor if you have a heart condition, thyroid disease, liver disease, glaucoma, or a problem with urination before starting treatment.